Nair Sandeep P, Sackellares J Chris, Shiau Deng-Shan, Norman Wendy M, Dance Linda K, Pardalos Panos M, Principe Jose C, Carney Paul R
Dept. of Biomed. Eng., Florida Univ., Gainesville, FL 32611-6131, USA.
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:4382-6. doi: 10.1109/IEMBS.2006.260830.
Progressive preictal dynamical convergence and postictal divergence of dynamical EEG descriptors among brain regions has been reported in human temporal lobe epilepsy (TLE) and in a rodent model of TLE. There are also reports of anticonvulsant effects of high frequency stimulation of the hippocampus in humans. We postulate that this anticonvulsant effect is due to dynamical resetting by the electrical stimulation. The following study investigated the effects of acute hippocampal electrical stimulation on dynamical transitions in the brain of a spontaneously seizing animal model of TLE to test the hypothesis of divergence in dynamical values by electrical stimulation of the hippocampus.
在人类颞叶癫痫（TLE）以及TLE啮齿动物模型中，已报道脑区之间动态脑电图描述符在发作前呈现渐进性动态收敛，在发作后呈现发散。也有关于人类海马体高频刺激抗惊厥作用的报道。我们推测这种抗惊厥作用是由于电刺激导致的动态重置。以下研究调查了急性海马体电刺激对TLE自发癫痫发作动物模型大脑中动态转变的影响，以检验海马体电刺激导致动态值发散这一假设。
