环状氨基磺酸酯作为亚烷基吡咯烷和哌啶的前体。
Cyclic sulfamidates as precursors to alkylidene pyrrolidines and piperidines.
作者信息
Bower John F, Szeto Peter, Gallagher Timothy
机构信息
School of Chemistry, University of Bristol, Bristol, U.K.
出版信息
Org Lett. 2007 Nov 8;9(23):4909-12. doi: 10.1021/ol7022104. Epub 2007 Oct 20.
PMID:17949100
Abstract
The reaction of the dienolate of ethyl acetoacetate (and related dienolates) with a range of 1,2- and 1,3-cyclic sulfamidates provides an entry to substituted and enantiopure alkylidenated pyrrolidines and piperidines. These heterocycles function as convenient precursors to heterocyclic beta-amino acid derivatives.
摘要
乙酰乙酸乙酯的烯醇负离子（以及相关烯醇负离子）与一系列1,2-和1,3-环亚磺酰胺的反应为合成取代的对映体纯亚烷基化吡咯烷和哌啶提供了一条途径。这些杂环化合物是杂环β-氨基酸衍生物的便捷前体。
Zotero 插件