烯基胺的加氢甲酰化反应。哌啶、喹诺里嗪和相关生物碱的简洁方法。

Hydroformylation of alkenylamines. Concise approaches toward piperidines, quinolizidines, and related alkaloids.

机构信息

Laboratoire d'Innovation Thérapeutique, UMR 7200, Faculté de Pharmacie, Université de Strasbourg, 74, route du Rhin, 67401 Illkirch Graffenstaden, France.

出版信息

J Org Chem. 2010 Dec 17;75(24):8670-3. doi: 10.1021/jo101776y. Epub 2010 Nov 17.

DOI:10.1021/jo101776y

PMID:21082772

Abstract

Linear hydroformylation of N-protected allyl- or homoallylamines (cyclohydrocarbonylation: CHC), followed by a reductive amination constitute the two key steps toward convenient routes to aza-heterocycles.

摘要

线性氢甲酰化 N-保护的烯丙基或同丙烯基胺（环加氧碳化：CHC），随后进行还原胺化，这两步是构建方便的氮杂环合成途径的两个关键步骤。