Wehn Paul M, Du Bois J
Amgen, Inc. 1120 Veterans Blvd., South San Francisco, CA 94080, USA.
Angew Chem Int Ed Engl. 2009;48(21):3802-5. doi: 10.1002/anie.200806292.
Weaving an intricate web: A stereoselective synthesis of (-)-agelastatin A has been developed, which requires 11 steps from commercially available starting material. The application of a Rh-catalyzed intramolecular olefin aziridination reaction and the subsequent manipulation of the resulting tricyclic intermediate (see scheme) punctuate this study.
已开发出一种(-)-agelastatin A的立体选择性合成方法,从市售起始原料开始需要11步。铑催化的分子内烯烃氮杂环丙烷化反应的应用以及所得三环中间体的后续操作(见方案)是本研究的亮点。