Jayabalan M, Kumar N S, Rathinam K, Kumari T V
Division for Technical Evaluation of Biomaterials, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
J Biomed Mater Res. 1991 Dec;25(12):1431-42. doi: 10.1002/jbm.820251203.
A cage implantation technique has been adopted in a rabbit animal model to investigate the biocompatibility of an aliphatic crosslinked polyurethane based on hexamethylene diisocyanate (HDI). In this study, four cages are represented; the cage containing the candidate polyurethane material, biomedical grade polyurethane (Tecoflex), the commercial grade polyvinylchloride (PVC), and an empty cage which were implanted subcutaneously in rabbits. Exudates were aspirated from these cages at 4, 7, 14, and 21 days postimplantation. Exudates were analyzed for variations in proteins, cell counts, and extracellular enzymes. Results with the four types of cage implants showed that the candidate polyurethane caused an inflammatory response comparable to that caused by medical-grade Tecoflex and the empty cage control.
在兔动物模型中采用了笼植入技术，以研究基于六亚甲基二异氰酸酯（HDI）的脂肪族交联聚氨酯的生物相容性。在本研究中，展示了四个笼子；装有候选聚氨酯材料的笼子、生物医学级聚氨酯（Tecoflex）、商业级聚氯乙烯（PVC）以及一个空笼子，它们被皮下植入兔子体内。在植入后第4、7、14和21天从这些笼子中抽取渗出液。对渗出液进行蛋白质、细胞计数和细胞外酶变化的分析。四种类型的笼植入物的结果表明，候选聚氨酯引起的炎症反应与医学级Tecoflex和空笼子对照引起的炎症反应相当。
