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生物医学用脂肪族聚氨酯的合成、表征及血液相容性研究

[Synthesis, characterization and blood compatibility studies of biomedical aliphatic polyurethanes].

作者信息

Du Minhui, Li Jianshu, Wei Yang, Xie Xingyi, He Chengsheng, Fan Cuirong, Zhong Yinping

机构信息

Department of Polymer, Sichuan University, Chengdu 610065.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2003 Jun;20(2):273-6.

Abstract

The one-step method was adopted in this study to synthesize aliphatic polyurethane with 4,4-methylene dicyclohexyl diisocyanate(HMDI), 1,4-butanediol (BDO) and poly (tetrahydrofuran) (PTMG). The tests conducted on this material were: FIR spectrum, mechanical properties test, water contact angles test, hemolysis test and platelet adhesion test. Results showed that this material has a good tensile strength up to 30 Mpa, similar to aromaphatic polyurethane. But its tensile elongation, tensile permanent change, hydrophility are better than those of aromaphatic polyurethane. The hemolysis test and platelet adhesion test showed that it has good blood compatibility.

摘要

本研究采用一步法,以4,4'-亚甲基二环己基二异氰酸酯(HMDI)、1,4-丁二醇(BDO)和聚四氢呋喃(PTMG)合成脂肪族聚氨酯。对该材料进行的测试有:红外光谱测试、力学性能测试、水接触角测试、溶血试验和血小板黏附试验。结果表明,该材料具有良好的拉伸强度,高达30兆帕,与芳香族聚氨酯相似。但其拉伸伸长率、拉伸永久变化率、亲水性均优于芳香族聚氨酯。溶血试验和血小板黏附试验表明其具有良好的血液相容性。

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