治疗性心肌血管生成
Therapeutic myocardial angiogenesis.
作者信息
Renault Marie-Ange, Losordo Douglas W
机构信息
Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave., Tarry 12-703, Chicago, IL 60611, USA.
出版信息
Microvasc Res. 2007 Sep-Nov;74(2-3):159-71. doi: 10.1016/j.mvr.2007.08.005. Epub 2007 Sep 7.
Abstract
Armed with an improved understanding of the mediators of angiogenesis, physicians and scientists have made significant efforts at harnessing this naturally occurring process in order to treat patients with a variety of peripheral vascular and coronary ischemic syndromes. There is a growing population of patients with end-stage coronary artery disease (CAD) who are no longer candidates for mechanical revascularization, yet suffer from chronic myocardial ischemia who may benefit from regeneration of the depleted microvasculature.
摘要
凭借对血管生成介质的深入了解，医生和科学家们为利用这一自然过程付出了巨大努力，以治疗各种外周血管和冠状动脉缺血综合征患者。越来越多终末期冠状动脉疾病（CAD）患者不再适合进行机械血运重建，但患有慢性心肌缺血，他们可能从枯竭的微血管再生中获益。
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