Annex Brian H, Simons Michael
Division of Cardiology, Department of Medicine, Durham Veterans Administration, Duke University Medical Center, Durham, NC, USA.
Cardiovasc Res. 2005 Feb 15;65(3):649-55. doi: 10.1016/j.cardiores.2004.09.004.
Therapeutic angiogenesis, stimulated growth of new vasculature to compensate for tissue ischemia, remains an unfulfilled promise. After nearly a decade of trials, the development of drugs capable of stimulating revascularization of underperfused tissues remains an exciting but unrealized goal in cardiovascular therapeutics. This review will summarize experiences in therapeutic angiogenesis studies employing protein therapies and will draw conclusions based on our current understanding of biological processes of new vessel growth.
治疗性血管生成，即刺激新血管生长以补偿组织缺血，仍是一个尚未实现的目标。经过近十年的试验，开发能够刺激灌注不足组织血管再生的药物，在心血管治疗领域仍然是一个令人兴奋但尚未实现的目标。这篇综述将总结使用蛋白质疗法进行治疗性血管生成研究的经验，并将基于我们目前对新血管生长生物学过程的理解得出结论。
