乳香酸新型氨基类似物的细胞毒性和凋亡活性
Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids.
作者信息
Shah Bhahwal A, Kumar Ajay, Gupta Pankaj, Sharma Madhunika, Sethi Vijay K, Saxena Ajit K, Singh Jaswant, Qazi Ghulam N, Taneja Subhash C
机构信息
Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi 180001, India.
出版信息
Bioorg Med Chem Lett. 2007 Dec 1;17(23):6411-6. doi: 10.1016/j.bmcl.2007.10.011. Epub 2007 Oct 10.
PMID:17950603
Abstract
4-Amino analogues prepared from beta-boswellic acid and 11-keto-beta-boswellic acid, wherein the carboxyl group in ursane nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.
摘要
由β-乳香酸和11-酮-β-乳香酸制备的4-氨基类似物，其中乌苏烷核中的羧基通过库尔提斯反应被氨基官能团取代，其细胞毒性比母体分子有所提高。相同的分子还通过诱导DNA片段化表现出凋亡活性。
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