Chen Hong, Jing Fu Chun, Li Chang Ling, Tu Peng Fei, Zheng Qiu Sheng, Wang Zheng Hua
Ministry of Education, Key Laboratory of Xinjiang Phytomedicine Resources, Shihezi University, Shihezi 832002, China.
J Ethnopharmacol. 2007 Dec 3;114(3):285-9. doi: 10.1016/j.jep.2007.07.035. Epub 2007 Aug 11.
We investigated the effects of echinacoside, a phenylethanoid glycoside isolated and purified from the stems of Cistanche salsa, a Chinese herbal medicine, on the striatal extracellular levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in 6-hydroxydopamine (6-OHDA) lesion rats. Seven days after 6-OHDA was injected into the right striatum of rats, the striatal extracellular levels of DA, DOPAC and HVA fell significantly (P<0.01 vs. vehicle), as demonstrated by the method of cerebral microdialysis and high performance liquid chromatography with electrochemical detection. However, simultaneous treatment with echinacoside (7.0, 3.5mg/kg) attenuated the diminution of them (P<0.01 vs. model). The results implied that echinacoside could protect the striatal dopaminergic neurons from injury induced by 6-OHDA and may be useful in the prevention and treatment of Parkinson's disease (PD).
我们研究了松果菊苷（一种从中药材肉苁蓉茎中分离纯化得到的苯乙醇苷）对6-羟基多巴胺（6-OHDA）损伤大鼠纹状体细胞外多巴胺（DA）、3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）水平的影响。大鼠右侧纹状体注射6-OHDA 7天后，采用脑微透析和高效液相色谱电化学检测法显示，纹状体细胞外DA、DOPAC和HVA水平显著下降（与溶剂对照组相比，P<0.01）。然而，同时给予松果菊苷（7.0、3.5mg/kg）可减轻它们的减少（与模型组相比，P<0.01）。结果表明，松果菊苷可保护纹状体多巴胺能神经元免受6-OHDA诱导的损伤，可能对帕金森病（PD）的预防和治疗有用。
