Zhang Ying, Wang Yuewu, Yang Song, Xiao Yunfeng, Guan Haibin, Yue Xin, Wang Xiaoqin, Li Xiangri
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Higher Education Park, Beijing 102488, China.
School of Pharmacy, Inner Mongolia Medical University, Jinshan Development Zone, Hohhot, Inner Mongolia 010110, China.
Evid Based Complement Alternat Med. 2019 Mar 17;2019:2167947. doi: 10.1155/2019/2167947. eCollection 2019.
As a well-known Chinese herb medicine, the Cistanche deserticola has been used for the treatment of kidney deficiency syndrome in China for thousands of years. Both the raw product of Cistanche deserticola slices (RCD) and its Wine Steam-Processed Product (WSCD) are used clinically for different effects. In this study, the influences of steaming process with wine (SPW) from Cistanche deserticola on chemical compositions and biological effects were investigated. The principal component analysis (PCA) and quantitative analysis were used to study the differences of the chemical compositions. The effects of nourishing kidney were also investigated to compare the differences between the RCD and the WSCD. The PCA results indicated that the obvious separation was achieved in the RCD and WSCD. The results of quantitative analysis showed that the WSCD has higher amounts of total polysaccharides, total PhGs, isoacteoside, and osmanthuside B than RCD, while the content of 2'-acetylacteoside and acteoside decreased after the SPW. The comparison of RCD and WSCD on biological activities showed that both could restore the level of sex hormone in the model of kidney-yang deficiency and improve the antioxidant effect. The WSCD were much better in increasing the viscera weight of kidney and seminal vesicle. The results indicated that SPW changed its chemical components and enhanced its biological activities.
肉苁蓉作为一种著名的中草药，在中国已被用于治疗肾虚证数千年。肉苁蓉片生品（RCD）及其酒蒸制品（WSCD）在临床上因功效不同而被使用。本研究考察了肉苁蓉酒蒸工艺（SPW）对其化学成分和生物学效应的影响。采用主成分分析（PCA）和定量分析研究化学成分的差异。还研究了补肾作用，以比较RCD和WSCD之间的差异。PCA结果表明，RCD和WSCD之间实现了明显分离。定量分析结果表明，WSCD的总多糖、总苯乙醇苷、异毛蕊花糖苷和木犀草苷B含量高于RCD，而经过SPW后，2'-乙酰毛蕊花糖苷和毛蕊花糖苷的含量降低。RCD和WSCD的生物学活性比较表明，两者均可恢复肾阳虚模型中性激素水平并提高抗氧化作用。WSCD在增加肾脏和精囊脏器重量方面效果更佳。结果表明，SPW改变了其化学成分并增强了其生物学活性。
