Bhatavdekar J M, Patel D D, Vora H H, Balar D B
Division of Research, Gujarat Cancer Society, Ahmedabad, India.
Int J Biol Markers. 1991 Oct-Dec;6(4):237-40. doi: 10.1177/172460089100600404.
Serum squamous cell carcinoma antigen (SCCAg) and protein-bound sialic acid (PBSA) were measured in 43 head and neck cancer patients and 50 controls. SCCAg and PBSA were correlated with clinical stage, histological grade, presence/absence of keratin and disease course. Patients with advanced cancer (stage III and IV) and grade III tumors had higher PBSA levels but no such difference was observed for SCCAg. Head and neck cancer patients were grouped according to the disease status i.e. a) patients who developed recurrence and b) who responded to the adjuvant therapies. There was an excellent correlation between serial serum PBSA changes and the progression of disease or the response to therapy in patients with advanced head and neck cancer.
对43例头颈癌患者和50例对照者测定了血清鳞状细胞癌抗原（SCCAg）和蛋白结合唾液酸（PBSA）。SCCAg和PBSA与临床分期、组织学分级、有无角化及病程相关。晚期癌症（Ⅲ期和Ⅳ期）患者及Ⅲ级肿瘤患者的PBSA水平较高，但SCCAg未观察到此类差异。根据疾病状态将头颈癌患者分组，即a）发生复发的患者和b）对辅助治疗有反应的患者。在晚期头颈癌患者中，血清PBSA系列变化与疾病进展或治疗反应之间存在极好的相关性。
