Straka M B, Wagner R L, Johnson J T, Kachman K K, Eibling D E
Department of Otolaryngology, University of Pittsburgh School of Medicine, PA.
Arch Otolaryngol Head Neck Surg. 1992 Aug;118(8):802-5. doi: 10.1001/archotol.1992.01880080024007.
An ideal tumor marker should be sensitive in tumor-bearing patients while having adequate specificity so that controls do not demonstrate the marker. To date, a single circulating marker has not been identified for squamous cell carcinoma of the head and neck. This study evaluates a panel including squamous cell carcinoma radioimmunoassay, lipid-associated sialic acid, carcinoembryonic antigen, and CA-125. In this population of patients with cancer, serum samples from 101 patients and 88 controls were evaluated. The squamous cell carcinoma radioimmunoassay was the most sensitive marker identified (47.5%), while carcinoembryonic antigen level was elevated in 40.6%, lipid-associated sialic acid level in only 16.8%, and CA-125 level in 7.9%. False-positive results were found with all markers, including squamous cell carcinoma radioimmunoassay (18.2%), carcinoembryonic antigen (18.2%), lipid-associated sialic acid (10.2%), and CA-125 (15.9%). Various combinations of markers did not significantly improve either specificity or sensitivity. Available tumor markers are inadequate for diagnostic purposes in patients with squamous cell carcinoma of the head and neck.
理想的肿瘤标志物应对肿瘤患者具有敏感性，同时具有足够的特异性，以使对照者不显示该标志物。迄今为止，尚未发现针对头颈部鳞状细胞癌的单一循环标志物。本研究评估了一个标志物组合，包括鳞状细胞癌放射免疫测定、脂质相关唾液酸、癌胚抗原和CA - 125。在这群癌症患者中，对101例患者和88例对照者的血清样本进行了评估。鳞状细胞癌放射免疫测定是所鉴定出的最敏感的标志物（47.5%），而癌胚抗原水平升高的占40.6%，脂质相关唾液酸水平升高的仅占16.8%，CA - 125水平升高的占7.9%。所有标志物均发现有假阳性结果，包括鳞状细胞癌放射免疫测定（18.2%）、癌胚抗原（18.2%）、脂质相关唾液酸（10.2%）和CA - 125（15.9%）。标志物的各种组合并未显著提高特异性或敏感性。现有的肿瘤标志物在头颈部鳞状细胞癌患者的诊断中并不充分。
