Träger Jens, Heinzer Jasmin, Kim Hee-Cheol, Hampp Norbert
University of Marburg, Department of Chemistry, Hans-Meerwein-Strasse, 35032 Marburg, Germany.
Macromol Biosci. 2008 Feb 11;8(2):177-83. doi: 10.1002/mabi.200700155.
High-refractive-index polymers for intraocular lenses are presented whose refractive index can be tuned post-operatively in a non-invasive manner to enable focal length and aspheric corrections in vivo. The polymer materials contain covalently attached photochemically crosslinkable coumarin side groups, to cause a change in refractive index of Deltan > 0.02, which enables one to tune the focal length of a standard IOL by two diopters. This is enough to ensure that more than 80% of all cataract patients can be adjusted non-invasively to optimal vision after cataract surgery, thus providing a remedy to a major shortcoming of today's cataract surgery.
本文介绍了用于人工晶状体的高折射率聚合物，其折射率可在术后以非侵入性方式进行调节，以实现体内焦距和非球面矫正。聚合物材料含有共价连接的可光化学交联香豆素侧基，可导致折射率变化Δn>0.02，这使得能够将标准人工晶状体的焦距调节两个屈光度。这足以确保所有白内障患者中超过80%能够在白内障手术后通过非侵入性方式调整到最佳视力，从而弥补了当今白内障手术的一个主要缺点。
