Yuan Nan-bing, Wang Chun, Wang Yan, Yu Ting-ting, Shu Shi-qing, Liu Min, Ran Xing-wu
Diabetic Foot Care Center, Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Sep;38(5):900-3.
To assess the effectiveness and security of autologous platelet-rich gel (APG) in the treatment of refractory diabetic dermal ulcers.
Thirteen diabetic patients with refractory skin lesions were enrolled for this study, and APG was produced by platelet (PLT)-rich plasma (PRP) with thrombin and calcium gluconate. APG treatment consisted of wound dressed with APG, followed by topical washing and cleaning. The APG was then covered with Vaseline gauze and left for 48 to 72 hours, after which the wounds were treated conventionally until the next PLT-gel treatment. The clinical endpoints of the study were the healing rate.
A total of 13 patients entered the pilot study. There were no drop-outs in the study. 69.2% ulcers were cured, and especially the ulcer areas were reduced significantly in the first 3 weeks; no adverse reactions were observed.
Topical therapy with APG may be considered as an effective adjuvant method to treating refractory diabetic dermal ulcer.
评估自体富血小板凝胶（APG）治疗难治性糖尿病皮肤溃疡的有效性和安全性。
本研究纳入了13例患有难治性皮肤损伤的糖尿病患者，通过富含血小板（PLT）的血浆（PRP）与凝血酶和葡萄糖酸钙制备APG。APG治疗包括用APG覆盖伤口，随后进行局部冲洗和清洁。然后用凡士林纱布覆盖APG并留置48至72小时，之后对伤口进行常规处理，直至下一次血小板凝胶治疗。本研究的临床终点是愈合率。
共有13例患者进入初步研究。研究中无脱落病例。69.2%的溃疡治愈，尤其是在最初3周溃疡面积显著减小；未观察到不良反应。
APG局部治疗可被视为治疗难治性糖尿病皮肤溃疡的一种有效辅助方法。
