Li Hong-Yuan, Ren Guo-Sheng, Arnould Nasrin, Brettes Jean-Philippe
Department of General Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhonghua Wai Ke Za Zhi. 2007 Jul 1;45(13):874-6.
To evaluate the biological behavior and treatment method for the breast atypical lobular hyperplasia (ALH) and breast lobular carcinoma in situ (LCIS).
Seventeen cases of ALH and thirty-five cases of LCIS were reviewed from July 1982 to January 1996. All cases were followed by physical examination, mammography and B-ultrasound for an average of 146.6 months (range, 3 - 257 months).
Most cases of ALH and LCIS occurred before menopause (about 69.2%). Fifty-two cases of ALH and LCIS were occasionally verified pathologically after surgery for benign diseases. The microcalcification with ALH and LCIS had been detected in 25 cases, accounted for 48.1%. Eight cases of ALH/LCIS became invasive carcinoma. There were 5 cases in the same breast, 3 cases in the contralateral breast; The subsequent breast cancer occurred longer than nine years after ALH/LCIS was diagnosed. The family history of breast carcinoma and ovary carcinoma occurred in 4 cases of breast carcinoma, accounted for 50%, but it was no significant (P > 0.05). Also, there was no difference between LCIS and ALH, which occurred the breast carcinoma (P > 0.05).
The excisional biopsy might be necessary to ALH and LCIS.
评估乳腺非典型小叶增生（ALH）和乳腺小叶原位癌（LCIS）的生物学行为及治疗方法。
回顾性分析1982年7月至1996年1月间17例ALH和35例LCIS患者。所有病例均接受体格检查、乳腺X线摄影及B超检查，平均随访146.6个月（范围3 - 257个月）。
大多数ALH和LCIS病例发生在绝经前（约69.2%）。52例ALH和LCIS患者在因良性疾病手术时偶然经病理证实。25例检测到ALH和LCIS伴有微钙化，占48.1%。8例ALH/LCIS发展为浸润性癌。同侧乳腺5例，对侧乳腺3例；后续乳腺癌发生在ALH/LCIS诊断后9年以上。4例乳腺癌患者有乳腺癌和卵巢癌家族史，占50%，但差异无统计学意义（P>0.05）。此外，LCIS和ALH发生乳腺癌的情况无差异（P>0.05）。
对于ALH和LCIS可能需要进行切除活检。
