Herford Alan S, Boyne Philip J, Rawson Rick, Williams Roland P
Department of Oral and Maxillofacial Surgery, Loma Linda University Medical Center, Loma Linda, CA 92350, USA.
J Oral Maxillofac Surg. 2007 Nov;65(11):2136-41. doi: 10.1016/j.joms.2007.06.670.
The purpose of this study is to evaluate the bony regeneration of premaxillary clefts in humans using recombinant human bone morphogenetic protein type 2 in a collagen sponge carrier.
Twelve patients with unilateral clefted premaxillas were evaluated preoperatively and 4 months postoperatively. Ten patients were repaired with recombinant human bone morphogenetic protein type 2 while 2 others were grafted with anterior iliac crest particulate marrow cancellous bone. Computed tomographic studies were used to evaluate preoperative alveolar cleft volumes, postoperative bone bridge volumes, and preoperative and postoperative volume ratios.
A preoperative and postoperative volume ratio for patients repaired with recombinant human bone morphogenetic protein type 2 ranged from 24.1% to 90.6% with a mean of 71.7%. Patients who were grafted with particulate marrow cancellous bone had similar preoperative and postoperative volume ratios ranging from 71.3% to 84.9% with a mean of 78.1%.
Clefts of the anterior maxilla can have complete osseous regeneration induced by recombinant human bone morphogenetic protein type 2 as an effective alternative to conventional anterior iliac particulate marrow cancellous bone grafts.
本研究旨在评估使用胶原海绵载体中的重组人骨形态发生蛋白2对人类上颌前部裂隙进行骨再生的情况。
对12例单侧上颌前部裂隙患者进行术前及术后4个月的评估。10例患者采用重组人骨形态发生蛋白2修复，另外2例采用髂前嵴颗粒状骨髓松质骨移植。采用计算机断层扫描研究评估术前牙槽裂体积、术后骨桥体积以及术前和术后体积比。
采用重组人骨形态发生蛋白2修复的患者术前与术后体积比在24.1%至90.6%之间，平均为71.7%。采用颗粒状骨髓松质骨移植的患者术前与术后体积比相似，在71.3%至84.9%之间，平均为78.1%。
重组人骨形态发生蛋白2可诱导上颌前部裂隙实现完全骨再生，作为传统髂前颗粒状骨髓松质骨移植的有效替代方法。
