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rhBMP-2 负载的 3D 打印异体-颗粒型移植物的骨再生。

Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2.

机构信息

Department of Pediatric Dentistry, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea.

Graduate School of Clinical Dentistry, Hallym University, Chuncheon 24252, Korea.

出版信息

Int J Mol Sci. 2021 Nov 20;22(22):12518. doi: 10.3390/ijms222212518.

DOI:10.3390/ijms222212518
PMID:34830400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8624569/
Abstract

This study aimed to evaluate the bone regeneration capacity of a customized alloplastic material and xenograft with recombinant human bone morphogenetic protein-2 (rhBMP-2). We prepared hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic bone blocks made using a 3D printing system and added rhBMP-2 to both materials. In eight beagle dogs, a total of 32 defects were created on the lower jaws. The defective sites of the negative control group were left untreated (N group; 8 defects), and those in the positive control group were filled with particle-type Bio-Oss (P group; 12 defects). The defect sites in the experimental group were filled with 3D-printed synthetic bone blocks (3D group; 12 defects). Radiographic and histological evaluations were performed after healing periods of 6 and 12 weeks and showed no significant difference in new bone formation and total bone between the P and 3D groups. The 3D-printed custom HA/TCP graft with rhBMP-2 showed bone regeneration effects similar to that of particulate Bio-Oss with rhBMP-2. Through further study and development, the application of 3D-printed customized alloplastic grafts will be extended to various fields of bone regeneration.

摘要

本研究旨在评估定制型同种异体材料和重组人骨形态发生蛋白-2（rhBMP-2）的异种移植物的骨再生能力。我们使用 3D 打印系统制备了羟基磷灰石（HA）/磷酸三钙（TCP）纯陶瓷骨块，并向两种材料中添加了 rhBMP-2。在 8 只比格犬中，在下颌骨上共创建了 32 个缺陷。阴性对照组的缺陷部位未进行处理（N 组；8 个缺陷），阳性对照组的缺陷部位填充了颗粒型 Bio-Oss（P 组；12 个缺陷）。实验组的缺陷部位填充了 3D 打印合成骨块（3D 组；12 个缺陷）。在 6 周和 12 周的愈合期后进行了影像学和组织学评估，结果显示 P 组和 3D 组之间新骨形成和总骨量无显著差异。含有 rhBMP-2 的 3D 打印定制 HA/TCP 移植物具有与含有 rhBMP-2 的颗粒状 Bio-Oss 相似的骨再生效果。通过进一步的研究和开发，3D 打印定制同种异体移植物的应用将扩展到骨再生的各个领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/cce60b19acc4/ijms-22-12518-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/4ca231d0d09f/ijms-22-12518-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/255fa66d24ac/ijms-22-12518-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/8a8f0fba9a3d/ijms-22-12518-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/f801ff732c3f/ijms-22-12518-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/cce60b19acc4/ijms-22-12518-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/4ca231d0d09f/ijms-22-12518-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/255fa66d24ac/ijms-22-12518-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/8a8f0fba9a3d/ijms-22-12518-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/f801ff732c3f/ijms-22-12518-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb07/8624569/cce60b19acc4/ijms-22-12518-g005.jpg

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