McLeish S, Turner S W
Department of Child Health, University of Aberdeen, Aberdeen, UK.
Arch Dis Child. 2007 Nov;92(11):1032-5. doi: 10.1136/adc.2006.112185.
The underlying pathogenesis of asthma, one of the most common chronic diseases of childhood, is not fully understood. There is a well-documented heritable component to this disease and environmental factors associated with a Westernised lifestyle have also been implicated; recent studies suggest gene-environment interactions are important in the development of this disease. In the absence of a previous review in children, the present report presents the accumulating evidence for gene-environment interactions in asthma pathogenesis. Studies of these interactions in different populations have yielded both expected and unexpected results. This is a new and rapidly developing field where there are currently many more questions than answers.
哮喘是儿童期最常见的慢性病之一，其潜在发病机制尚未完全明确。该疾病存在遗传因素，且与西方化生活方式相关的环境因素也有牵连；最近的研究表明基因与环境的相互作用在该疾病的发展过程中至关重要。鉴于此前尚无针对儿童的相关综述，本报告呈现了哮喘发病机制中基因与环境相互作用的累积证据。对不同人群中这些相互作用的研究产生了既在意料之中又在意料之外的结果。这是一个新的且快速发展的领域，目前问题远多于答案。
