Knyshov G V, Vykhovaniuk I V, Tkhor N V, Korchinskaia O I, Stroganova N P, Furkalo S N
Kardiologiia. 1991 Aug;31(8):26-30.
The hemodynamic pattern of the antianginal effects of calcium antagonists was examined in 111 patients with Functional Classes II-IV angina pectoris relapsing on an average of 36.7 +/- 1.1 months following aortocoronary bypass surgery, as evidenced by radionuclide ventriculography performed in the acute drug test with finoptin and corinfar. The clinical and functional status improved in 49 patients on finoptin and in 62 on corinfar. In three fourths, the efficacy of finoptin was achieved by decreased myocardial diastolic stiffness and only in a fourth, it was due to lower afterload. In three fourths, the efficacy of corinfar was attained by the action of the vascular component and only in a fourth, it was attributable to its effects on diastolic relaxation--to its direct action on the myocardium.
在111例患有II-IV级功能性心绞痛的患者中，研究了钙拮抗剂抗心绞痛作用的血流动力学模式。这些患者在主动脉冠状动脉搭桥手术后平均36.7 +/- 1.1个月复发心绞痛，这在使用心得安和心可定进行的急性药物试验中通过放射性核素心室造影得到证实。服用心得安的49例患者和服用心可定的62例患者的临床和功能状态有所改善。在四分之三的患者中，心得安的疗效是通过降低心肌舒张硬度实现的，只有四分之一的患者是由于后负荷降低。在四分之三的患者中，心可定的疗效是通过血管成分的作用实现的，只有四分之一的患者归因于其对舒张期松弛的影响——对心肌的直接作用。
