Zeĭnalov F I, Malov A G, Mazur N A, Sergienko V B, Sumarokov A B, Rubanovich A I
Kardiologiia. 1991 Jun;31(6):51-4.
The intracardiac hemodynamics was studied in 33 patients with exertional angina pectoris undergoing an acute drug test with verapamil (n-15) and nifedipine (n-18) by using radionuclide ventriculography both at rest and during exercise. All the patients were divided into 2 groups by the increase in exercise duration with the two drugs: 1) those who exhibited a marked antianginal effect and 2) those without it. At rest, the calcium antagonists enhanced ejection fraction in the two groups. Exercise ejection fraction also increased, but in a subgroup of patients who displayed no higher exercise tolerance with verapamil. Verapamil and nifedipine in Group 1 patients resulted in lower left ventricular end diastolic volume. It is suggested that the antianginal effect of calcium antagonists is to a certain degree associated with decreased afterload, as manifested by diminished left ventricular end systolic volume.
通过放射性核素心室造影术，对33例劳力性心绞痛患者在静息和运动时进行急性药物试验，分别使用维拉帕米（n = 15）和硝苯地平（n = 18），研究其心内血流动力学。根据使用这两种药物后运动持续时间的增加情况，将所有患者分为两组：1）表现出明显抗心绞痛作用的患者；2）未表现出明显抗心绞痛作用的患者。静息时，钙拮抗剂可提高两组患者的射血分数。运动射血分数也有所增加，但在使用维拉帕米后运动耐量未提高的患者亚组中除外。第1组患者使用维拉帕米和硝苯地平后左心室舒张末期容积降低。提示钙拮抗剂的抗心绞痛作用在一定程度上与后负荷降低有关，表现为左心室收缩末期容积减小。
