氨氯地平和拉西地平的口服治疗，1,4 - 二氢吡啶衍生物对实验性内脏利什曼病具有活性。
Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis.
作者信息
Palit Partha, Ali Nahid
机构信息
Indian Institute of Chemical Biology, Infectious Diseases and Immunology Division, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
出版信息
Antimicrob Agents Chemother. 2008 Jan;52(1):374-7. doi: 10.1128/AAC.00522-07. Epub 2007 Oct 22.
Abstract
Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.
摘要
氨氯地平和拉西地平这两种传统抗高血压药物，口服给药时在体外和BALB/c小鼠体内均能抑制杜氏利什曼原虫感染。这些1,4 - 二氢吡啶衍生物通过剂量依赖性抑制氧消耗发挥作用，引发半胱天冬酶3样激活介导的寄生虫程序性细胞死亡。
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