两性霉素B脱氧胆酸盐（两性霉素B注射剂）热诱导重新配方制剂对杜氏利什曼原虫的活性。
Activity of a heat-induced reformulation of amphotericin B deoxycholate (fungizone) against Leishmania donovani.
作者信息
Petit C, Yardley V, Gaboriau F, Bolard J, Croft S L
机构信息
Laboratoire de Physicochimie Biomoléculaire et Cellulaire (CNRS ESA 7033), Université Pierre et Marie Curie, Paris, France.
出版信息
Antimicrob Agents Chemother. 1999 Feb;43(2):390-2. doi: 10.1128/AAC.43.2.390.
Abstract
The heat treatment of amphotericin B deoxycholate (Fungizone), which was previously shown to induce superaggregation and decrease the toxicity of the drug to mammalian cells, increased its activity against Leishmania donovani in BALB/c mice, whereas it reduced its toxicity. Heat treatment preserved the activity of Fungizone against L. donovani HU3-infected mouse peritoneal macrophages.
摘要
两性霉素B脱氧胆酸盐（两性霉素B，商品名：Fungizone）的热处理，此前已证明其可诱导超聚集并降低该药物对哺乳动物细胞的毒性，在BALB/c小鼠中增强了其对杜氏利什曼原虫的活性，同时降低了其毒性。热处理保留了两性霉素B对感染杜氏利什曼原虫HU3的小鼠腹腔巨噬细胞的活性。
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