Riedel R R, Schmitt A, Hartmann A
Abteilung für Neurologie, Universitätsklinik Bonn.
Klin Wochenschr. 1991 Dec 11;69(20):930-1. doi: 10.1007/BF01798543.
A 32-year-old, HIV-positive homosexual with Kaposi's sarcoma was given subcutaneous interferon-A (IFN) for two- and a-half months. The patient complained of ocular symptoms (ptosis of the left eyelid and intermittent diplopia) after the application of IFN-A. These symptoms persisted for the period of treatment and subsided after therapy was stopped. However after IFN-A was resumed, ptosis and diplopia recurred. Intensive serological and neurological diagnostic investigations failed to present any reason for these ocular symptoms. From data and the clinical appearance we suppose that in this case the patient suffered a pseudo-myasthenic reaction to IFN-A.
一名32岁、患有卡波西肉瘤的HIV阳性同性恋者接受了两个半月的皮下注射干扰素-A（IFN）治疗。患者在应用干扰素-A后出现眼部症状（左眼睑下垂和间歇性复视）。这些症状在治疗期间持续存在，停药后消退。然而，在重新使用干扰素-A后，上睑下垂和复视再次出现。全面的血清学和神经学诊断检查未能找出这些眼部症状的任何原因。根据数据和临床表现，我们推测该患者在这种情况下对干扰素-A发生了假重症肌无力反应。
