This paper addresses the issue of disadvantage and health and how gender also affects health inequalities. Socio-economic status has been found to influence access to many social determinants of health, such as education and employment, food and nutrition, work opportunities, and housing. Socio-economic status has also been found to greatly impact on a person's access to effective healthcare in Ireland. Ireland has one of the widest gaps between rich and poor in Europe. Women in less well-off socio-economic groups are at the greatest disadvantage with regard to health and have been found to be at greater risk of developing poor health. The health of disadvantaged women is compromised by: lack of education, lack of information, and lack of awareness of factors that contribute to disease. These issues are explored in the paper with special focus on cancer, mental health, cardiovascular disease and sexual health.