Sandhu S S, Dhesi J S, Gill B S, Svendsgaard D
Genetic Toxicology Division, US EPA, Research Triangle Park, NC 27711.
Mutagenesis. 1991 Sep;6(5):369-73. doi: 10.1093/mutage/6.5.369.
This study was a part of an international project sponsored by the Commission of the European Communities to evaluate the utility of certain bioassays including hexaploid wheat assay to identify potential aneugens. Ten suspect spindle poisons, i.e. colchicine (COL), cadmium chloride (CdCl2), chloral hydrate (CH), diazepam (DIZ), econazole (EZ), hydroquinone (HQ), pyrimethamine (PY), thiabendazole (TB), thimerosal (TM), and vinblastin sulphate (VBL) were tested for their ability to induce green and/or white leaf sectors as indicators of loss or gain of a chromosome respectively, in Neatby's strain of Chinese Spring wheat (2n = 6x = 42). All the chemicals tested in this study, with the exception of CH and HQ yielded positive response.
本研究是由欧洲共同体委员会赞助的一个国际项目的一部分，该项目旨在评估某些生物测定法（包括六倍体小麦测定法）用于识别潜在非整倍体诱导剂的效用。对十种可疑纺锤体毒物，即秋水仙碱（COL）、氯化镉（CdCl2）、水合氯醛（CH）、地西泮（DIZ）、益康唑（EZ）、对苯二酚（HQ）、乙胺嘧啶（PY）、噻苯达唑（TB）、硫柳汞（TM）和硫酸长春碱（VBL）进行了测试，以检测它们分别在中国春小麦Neatby品系（2n = 6x = 42）中诱导绿色和/或白色叶扇区的能力，这些叶扇区分别作为染色体丢失或增加的指标。本研究中测试的所有化学物质，除CH和HQ外，均产生了阳性反应。
