Benoit O
URA CNRS 1159, hôpital de La Salpêtrière, Paris, France.
Neurophysiol Clin. 1991 Oct;21(4):245-65. doi: 10.1016/s0987-7053(05)80374-0.
Rationalisation of the war of hypnotics has recently been under discussion in France: a review of the benefits and risks of these substances may therefore be useful. Chronic insomnia is a result of multiple factors, among which individual characteristics of the personality play an important role. Hypnotic treatment is symptomatic; its beneficial influence on sleep progressively vanishes in few weeks, while some negative residual effects on daytime functioning (mood, alertness, performance, memory impairment) may persist. The main problems posed by hypnotic treatment with benzodiazepines are related to tolerance effects during the treatment period and to rebound insomnia and withdrawal phenomena after discontinuation. Practical issues for the treatment of insomnia, based on international consensus, are presented.
因此,对这些药物的益处和风险进行综述可能会有所帮助。慢性失眠是多种因素导致的结果,其中人格的个体特征起着重要作用。催眠治疗只是对症治疗;它对睡眠的有益影响在几周内就会逐渐消失,而对日间功能(情绪、警觉性、表现、记忆损害)的一些负面残留影响可能会持续存在。使用苯二氮䓬类药物进行催眠治疗带来的主要问题与治疗期间的耐受性效应以及停药后的反弹性失眠和戒断现象有关。本文还介绍了基于国际共识的失眠治疗实际问题。