Thomson Allan D, Cook Christopher C H, Guerrini Irene, Sheedy Donna, Harper Clive, Marshall E Jane
Molecular Psychiatry Laboratory, Windeyer Institute of Medical Science, Department of Mental Health Sciences, Royal Free and University College London, Medical School, 46 Cleveland Street, London W1T 4JF, UK.
Alcohol Alcohol. 2008 Mar-Apr;43(2):180-6. doi: 10.1093/alcalc/agm149. Epub 2007 Oct 23.
To develop clinical guidelines to identify individuals who misuse alcohol and are at risk of developing Wernicke's Encephalopathy (WE).
Non-systematic literature review of studies which includes a careful clinical record of the development of signs and symptoms of thiamine deficiency and in which the diagnosis of WE has been confirmed at autopsy.
The review of the clinical findings in cases of WE, diagnosed at autopsy, shows a consistent pattern of signs and symptoms. The pattern appears to be similar regardless of whether the thiamine deficiency is related to nutritional problems alone or associated with alcohol misuse.
The assessment of the degree of thiamine deficiency and the diagnosis of WE remain a clinical evaluation, and guidelines are suggested to help the clinician. Since neurotoxicity due to the metabolism of excessive alcohol in patients with chronic and severe alcohol dependence may be an important factor in determining long-term outcome of treatment, this must form part of the overall evaluation.
制定临床指南，以识别酒精滥用且有发生韦尼克脑病（WE）风险的个体。
对研究进行非系统性文献综述，这些研究包括对硫胺素缺乏体征和症状发展的详细临床记录，且在尸检时已确诊为WE。
对尸检确诊的WE病例的临床发现进行综述，显示出一致的体征和症状模式。无论硫胺素缺乏是仅与营养问题相关还是与酒精滥用相关，该模式似乎都相似。
硫胺素缺乏程度的评估和WE的诊断仍然是临床评估，建议制定指南以帮助临床医生。由于慢性和严重酒精依赖患者体内过量酒精代谢导致的神经毒性可能是决定治疗长期结果的重要因素，因此这必须成为整体评估的一部分。
