Morimoto T, Azuma A, Abe S, Usuki J, Kudoh S, Sugisaki K, Oritsu M, Nukiwa T
Dept of Internal Medicine, Division of Pulmonary Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyouku, Tokyo, Japan.
Eur Respir J. 2008 Feb;31(2):372-9. doi: 10.1183/09031936.00075307. Epub 2007 Oct 24.
The present study was designed to identify recent clinical phenotypes using the National Epidemiological Survey and to compare findings with those of previous surveys in Japan. Pathologically confirmed sarcoidosis cases newly diagnosed in 2004 were eligible for the present study. Disease parameters were recorded and compared. A total of 1,027 patients were enrolled from a cluster encompassing 79.4% of the entire Japanese population. The study participants consisted of 364 males and 663 females, providing an average incidence rate of 1.01 per 100,000 inhabitants (0.73 for males and 1.28 for females). The age-specific incidence rate displayed a biphasic pattern in the whole patient population and in the females. The male incidence rates peaked in the 20-34-yr-old group. A second peak for 50-60-yr-old females showed a higher incidence than the first younger peak. Patients with abnormalities in eyes, skin and cardiac laboratory findings accounted for 54.8, 35.4 and 23.0% of cases, respectively. The female/male incidence ratio was increased, and the frequency of eye and skin involvement and cardiac abnormality was higher than in previous surveys conducted in Japan. In conclusion, the data obtained in the present study differ from those of other countries and showed changes in sarcoidosis clinical phenotypes compared with previous studies in Japan.
本研究旨在利用全国流行病学调查确定近期的临床表型，并将研究结果与日本以往的调查结果进行比较。2004年新诊断的经病理证实的结节病病例符合本研究的条件。记录并比较疾病参数。从涵盖日本总人口79.4%的一个群组中总共招募了1027名患者。研究参与者包括364名男性和663名女性，平均发病率为每10万居民1.01例（男性为0.73例，女性为1.28例）。在整个患者群体和女性中，年龄特异性发病率呈现双相模式。男性发病率在20 - 34岁年龄组达到峰值。50 - 60岁女性的第二个峰值显示出比第一个较年轻峰值更高的发病率。眼睛、皮肤和心脏实验室检查结果异常的患者分别占病例的54.8%、35.4%和23.0%。女性/男性发病率比增加，眼睛和皮肤受累以及心脏异常的频率高于日本以往进行的调查。总之，本研究获得的数据与其他国家的数据不同，并且与日本以往的研究相比，结节病临床表型出现了变化。
