使用患有拉卡济病的人类和海豚的血清以及实验感染小鼠的血清对罗博氏拉卡菌抗原进行蛋白质印迹分析。
Use of sera from humans and dolphins with lacaziosis and sera from experimentally infected mice for Western Blot analyses of Lacazia loboi antigens.
作者信息
Mendoza Leonel, Belone Andréa F F, Vilela Raquel, Rehtanz Manuela, Bossart Gregory D, Reif John S, Fair Patricia A, Durden Wendy N, St Leger Judy, Travassos Luiz R, Rosa Patricia S
机构信息
Biomedical Laboratory Diagnostics Program, Michigan State University, 322 North Kedzie Hall, East Lansing, MI 48824-1031, USA.
出版信息
Clin Vaccine Immunol. 2008 Jan;15(1):164-7. doi: 10.1128/CVI.00201-07. Epub 2007 Oct 24.
Abstract
Antibodies in the sera of patients with lacaziosis recognized an approximately 193-kDa antigen and other Lacazia loboi antigens. Paracoccidioides brasiliensis gp43 antigen was detected by all evaluated sera, but they failed to detect a protein with the same molecular mass in L. loboi extracts. This study is the first to examine the humoral response to L. loboi antigens by using multiple host sera.
摘要
副球孢子菌病患者血清中的抗体识别出一种约193 kDa的抗原以及其他副球孢子菌抗原。所有评估的血清均检测到巴西副球孢子菌gp43抗原，但它们未能在副球孢子菌提取物中检测到具有相同分子量的蛋白质。本研究首次使用多种宿主血清检测对副球孢子菌抗原的体液反应。
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