腙衍生物的生物活性。
Biological activities of hydrazone derivatives.
作者信息
Rollas Sevim, Küçükgüzel S Güniz
机构信息
Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 34668, Turkey.
出版信息
Molecules. 2007 Aug 17;12(8):1910-39. doi: 10.3390/12081910.
Abstract
There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities.
摘要
人们对开发具有抗惊厥、抗抑郁、镇痛、抗炎、抗血小板、抗疟疾、抗菌、抗分枝杆菌、抗肿瘤、血管舒张、抗病毒和抗血吸虫病活性的新型化合物有着浓厚的兴趣。含有偶氮甲碱-NHN=CH-质子的腙是新药开发的一类重要化合物。因此，许多研究人员已将这些化合物合成为目标结构并评估其生物活性。这些观察结果为开发具有多种生物活性的新型腙提供了指导。
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