Chair and Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland.
Int J Mol Sci. 2021 Aug 30;22(17):9389. doi: 10.3390/ijms22179389.
Hydrazide-hydrazones possess a wide spectrum of bioactivity, including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antidepressant, antiviral, and antiprotozoal properties. This review is focused on the latest scientific reports regarding antibacterial, antimycobacterial, and antifungal activities of hydrazide-hydrazones published between 2017 and 2021. The molecules and their chemical structures presented in this article are the most active derivatives, with discussed activities having a hydrazide-hydrazone moiety as the main scaffold or as a side chain. Presented information constitute a concise summary, which may be used as a practical guide for further design of new molecules with antimicrobial activity.
酰腙类化合物具有广泛的生物活性，包括抗菌、抗结核、抗真菌、抗癌、抗炎、抗惊厥、抗抑郁、抗病毒和抗原生动物特性。本综述重点介绍了 2017 年至 2021 年间发表的关于酰腙类化合物的抗菌、抗分枝杆菌和抗真菌活性的最新科学报告。本文介绍的分子及其化学结构是最具活性的衍生物，具有酰腙类结构作为主要支架或侧链的讨论活性。所提供的信息是一个简洁的总结，可以作为进一步设计具有抗菌活性的新分子的实用指南。
