Miyata Mikiji, Tohnai Norimitsu, Hisaki Ichiro
Department of Material and Life Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Molecules. 2007 Aug 22;12(8):1973-2000. doi: 10.3390/12081973.
Steroidal bile acids and their derivatives exhibit characteristic inclusion behaviors in the crystalline state. Their crystals present varied assemblies due to asymmetric molecular structures, which relate to supramolecular properties through cooperative weak interactions. An overview indicates that the steroidal assemblies lie in an intermediate position among various molecules and have hierarchical structures such as primary, secondary, tertiary, and host-guest assemblies like proteins. Such an interpretation brought about the idea that the assemblies with dimensionality present supramolecular chirality such as three-axial, tilt, helical, bundle, and complementary chirality. This concept of the supramolecular chirality enables us to understand formation of chiral crystals starting from the molecular chirality of the steroidal molecules.
甾体胆汁酸及其衍生物在晶体状态下表现出独特的包合行为。由于其不对称的分子结构，它们的晶体呈现出多样的组装形式，这些组装形式通过协同弱相互作用与超分子性质相关。概述表明，甾体组装体处于各种分子的中间位置，并具有诸如一级、二级、三级等层次结构，以及类似蛋白质的主客体组装结构。这样的解释引出了一个观点，即具有维度性的组装体呈现出超分子手性，如三轴、倾斜、螺旋、束状和互补手性。超分子手性的这一概念使我们能够从甾体分子的分子手性出发理解手性晶体的形成。
