2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Org Biomol Chem. 2012 Aug 14;10(30):5985-92. doi: 10.1039/c2ob25072a. Epub 2012 Mar 29.
Molecular assemblies based on helical motifs are of substantial interest from the view point of fundamental science as well as application. In this study, we propose a new class of organic crystal, that is, heteroH-MOC (multi-component organic crystal containing different kinds of helical motifs consisted of different components), and describe successful construction of heteroH-MOCs with P2(1) and P2(1)2(1)2(1) space groups by using steroidal bile acids and cinchona alkaloids. In the P2(1) crystals, two kinds of helices composed of the steroid and alkaloid are arranged in a parallel fashion, while, in the P2(1)2(1)2(1) crystals, those are in a perpendicular fashion. It is remarkable that, in such systems, particularly in the latter crystals, components ingeniously achieved highly-ordered synchronization of periodicity (helical pitches r and periodic distances in the array of helices p), which is first demonstrated in this study through hierarchical interpretation of the crystal structures.
基于螺旋结构的分子组装体在基础科学和应用方面都具有重要的意义。在这项研究中，我们提出了一类新的有机晶体，即杂 H-MOC（包含不同种类螺旋结构的多组分有机晶体，这些螺旋结构由不同的成分组成），并描述了通过使用甾体胆汁酸和金鸡纳生物碱成功构建了具有 P2(1)和 P2(1)2(1)2(1)空间群的杂 H-MOC。在 P2(1)晶体中，由甾体和生物碱组成的两种螺旋以平行的方式排列，而在 P2(1)2(1)2(1)晶体中，它们以垂直的方式排列。值得注意的是，在这些体系中，特别是在后一种晶体中，各组分巧妙地实现了周期性（螺旋间距 r 和螺旋排列中的周期性距离 p）的高度有序同步，这是通过对晶体结构的层次解释首次在本研究中证明的。
