无过渡金属/路易斯酸条件下通过 C-C 键形成反应合成酰基苯并噻吩。

Department of Chemistry, MNR Post Graduate College, Kukatpally, Hyderabad-500072, India.

Beilstein J Org Chem. 2007 Oct 25;3:35. doi: 10.1186/1860-5397-3-35.

A simple and single-step synthesis of 2- and 3-acyl substituted benzothiophenes has been described via environmentally benign acylation of benzothiophene with in situ generated acyl trifluoroacetates. Both aliphatic and aromatic carboxylic acids participated in trifluoroacetic anhydride/phosphoric acid mediated C-C bond forming reactions under solvent-free conditions affording acyl benzothiophenes in good overall yields.

一种简单的一步法合成 2-和 3-酰基取代苯并噻吩的方法，是通过环境友好的苯并噻吩与原位生成的酰基三氟乙酸酯的酰化反应来实现的。在无溶剂条件下，脂肪族和芳香族羧酸都参与了三氟乙酸酐/磷酸介导的 C-C 键形成反应，以良好的总收率得到了酰基苯并噻吩。