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在无过渡金属条件下通过酰基氰的C-C键裂解合成α-杂芳烃甲酯

Synthesis of -Heteroarenemethyl Esters via C-C Bond Cleavage of Acyl Cyanides Under Transition Metal-Free Conditions.

作者信息

Lai Miao, Su Fangyao, Hu Jingyi, Wang Mengzhuo, Zhao Mingqin, Zhang Ganlin

机构信息

Flavors and Fragrance Engineering and Technology Research Center of Henan Province, College of Tobacco Science, Henan Agricultural University, Zhengzhou, China.

出版信息

Front Chem. 2022 Jan 27;9:822625. doi: 10.3389/fchem.2021.822625. eCollection 2021.

DOI:10.3389/fchem.2021.822625
PMID:35155384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8828493/
Abstract

A practical method to synthesize -heteroaryl esters from -heteroaryl methanols with acyl cyanides C-C bond cleavage without using any transition metal is demonstrated here. The use of NaCO/15-crown-5 couple enables access to a series of -heteroaryl esters in high efficiency. This protocol is operationally simple and highly environmentally benign producing only cyanides as byproducts.

摘要

本文展示了一种从杂芳基甲醇与酰基氰化物合成杂芳基酯的实用方法，该方法无需使用任何过渡金属即可实现C-C键裂解。使用NaCO/15-冠-5组合能够高效地获得一系列杂芳基酯。该方案操作简单，对环境高度友好，仅产生氰化物作为副产物。

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Catalytic conversion of ketones to esters via C(O)-C bond cleavage under transition-metal free conditions.
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