Fagioli S, Rossi-Arnaud C, Ammassari-Teule M
Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy.
Psychopharmacology (Berl). 1991;105(2):209-12. doi: 10.1007/BF02244311.
One month intact C57BL/6 mice were treated with GM1 ganglioside for 3 consecutive weeks. At 2 months of age, treated and control mice were observed in the open-field situation and tested for spatial learning in a radial eight-arm maze. The results showed that, in the open-field, treated mice displayed less freezing but more rearing behavior than control animals. In the radial maze, GM1-treated mice made more correct path choices before the first error within each trial than control mice. However, this improvement was limited to the first stage of training. These results suggest an early stimulating effect of the GM1 ganglioside treatment which could facilitate adaptive reactions to new situations.
将1个月大的C57BL/6纯合子小鼠连续3周给予GM1神经节苷脂治疗。在2个月大时，在旷场环境中观察经治疗的小鼠和对照小鼠，并在放射状八臂迷宫中测试其空间学习能力。结果显示，在旷场中，经治疗的小鼠比对照动物表现出更少的僵立不动，但更多的站起行为。在放射状迷宫中，经GM1治疗的小鼠在每次试验中首次出现错误之前做出的正确路径选择比对照小鼠更多。然而，这种改善仅限于训练的第一阶段。这些结果表明GM1神经节苷脂治疗具有早期刺激作用，可促进对新情况的适应性反应。
