长期给予神经节苷脂GM1对小鼠被动回避记忆保持的影响。
Effect of chronic GM1 ganglioside administration on passive avoidance retention in mice.
作者信息
Fagioli S, Castellano C, Oliverio A, Toffano G
机构信息
Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, Rome, Italy.
出版信息
Neurosci Lett. 1990 Feb 5;109(1-2):212-6. doi: 10.1016/0304-3940(90)90565-q.
PMID:2314637
Abstract
Chronic administration of GM1 ganglioside to C57BL/6 mice during development improved passive avoidance retention. A significant weight increase was also evident in the treated animals in comparison with the control group. The results are discussed in terms of the possible effects exerted by GM1 upon the cholinergic mechanisms of this inbred strain.
摘要
在发育过程中对C57BL/6小鼠长期给予GM1神经节苷脂可改善被动回避记忆。与对照组相比，接受治疗的动物体重也显著增加。就GM1对该近交系胆碱能机制可能产生的影响对结果进行了讨论。
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