Capito C, Leclair M-D, Piloquet H, Plattner V, Heloury Y, Podevin G
Pediatric Surgery Department, Medicine University of Nantes, Hôpital Mère-Enfant, F-44093, Nantes, France.
Surg Endosc. 2008 Apr;22(4):875-80. doi: 10.1007/s00464-007-9603-3. Epub 2007 Oct 26.
This study aimed to assess the long-term effects of laparoscopic Nissen-Rossetti fundoplication (LNF) on clinical and pH evaluations of children with gastroesophageal reflux disease (GERD) according to neurologic status.
The study examined 127 children (73 neurologically impaired and 54 neurologically normal with primary GERD) who consecutively underwent LNF from 1992 to 2003. The follow-up protocol included evaluations at 3, 15, and more than 36 months (long-term evaluation) postoperatively, which consisted of physical examination and 24-h pH monitoring. Recurrences were defined as abnormal pH-metry exhibited by symptomatic children.
The long-term follow-up period averaged 5.5 years. Of the 73 neurologically impaired children, 9 (12%) had GERD recurrences, which occurred during the evaluation period and required redo surgery in four cases, including two Bianchi procedures. In the neurologically normal group, one recurrence (2%) occurred 3 months after surgery. The long-term complications in this group included dyspepsia (n = 3), occasional dysphagia (n = 2), gas bloat syndrome (n = 1), and alimentary disorders (n = 2).
For children with primary GERD, LNF is a long-term efficient procedure. For the neurologically impaired children, the results were good, with more than 85% of the children symptom free after 5 years, although repeated evaluations are required to diagnose late recurrences related to evolving dysmotility disorders.
本研究旨在根据神经学状态评估腹腔镜尼森-罗塞蒂胃底折叠术(LNF)对胃食管反流病(GERD)患儿临床及pH值评估的长期影响。
该研究对1992年至2003年间连续接受LNF手术的127例患儿(73例神经功能受损患儿和54例原发性GERD神经功能正常患儿)进行了检查。随访方案包括术后3个月、15个月及36个月以上(长期评估)的评估,评估内容包括体格检查和24小时pH值监测。复发定义为有症状患儿出现异常pH值测定结果。
长期随访期平均为5.5年。在73例神经功能受损患儿中,9例(12%)出现GERD复发,复发发生在评估期内,4例需要再次手术,其中包括2例比安奇手术。在神经功能正常组中,1例(2%)在术后3个月复发。该组的长期并发症包括消化不良(n = 3)、偶尔吞咽困难(n = 2)、气胀综合征(n = 1)和消化紊乱(n = 2)。
对于原发性GERD患儿,LNF是一种长期有效的手术方法。对于神经功能受损患儿,结果良好,超过85%的患儿在5年后无症状,尽管需要反复评估以诊断与逐渐发展的动力障碍相关的晚期复发。