Song Y, Yu J R
Department of Physiology, Beijing Medical University.
Sheng Li Xue Bao. 1991 Oct;43(5):428-35.
The effect of bombesin against injury on rat islet B cells was studied in three kinds of experiments: (1). In vivo experiment, it was found that preinjection of bombesin (50 micrograms/kg, sublingual v.) could effectively prevent an increase of plasma glucose and decrease of plasma insulin in diabetic rat induced by alloxan (200 mg/kg, s.c.) (2). In vitro experiment, isolated pancreas perfusion showed that alloxan-induced (14 mmol/L) perfusion fluid inhibition of insulin secretion could be reversed by pretreatment of bombesin (10(-3) mmol/L). (3). Investigation on isolated and incubated islets demonstrated that alloxan induced decrease of insulin and somatostatin secretion and increase of glucagon secretion could be prevented by bombesin. The above-mentioned results suggest that bombesin may play an important role in the regulation of plasma glucose in diabetic rat and have a potent preventive effect against the development of diabetes.
通过三种实验研究了蛙皮素对大鼠胰岛B细胞损伤的影响：（1）.体内实验发现，预先注射蛙皮素（50微克/千克，舌下给药）可有效防止由四氧嘧啶（200毫克/千克，皮下注射）诱导的糖尿病大鼠血糖升高和血浆胰岛素降低。（2）.体外实验中，分离胰腺灌注显示，蛙皮素（10⁻³毫摩尔/升）预处理可逆转四氧嘧啶（14毫摩尔/升）诱导的灌注液对胰岛素分泌的抑制作用。（3）.对分离并培养的胰岛进行的研究表明，蛙皮素可防止四氧嘧啶诱导的胰岛素和生长抑素分泌减少以及胰高血糖素分泌增加。上述结果表明，蛙皮素可能在糖尿病大鼠血糖调节中起重要作用，并且对糖尿病的发展具有强大的预防作用。
