Bezuglova T V, Iurkiv V A
Biull Eksp Biol Med. 1975 Jul;80(7):84-8.
Morphological changes in the lympho-reticular organs (the thymus, lymph nodes, spleen) were studied and the content of the RNA was determined by the biochemical method in 92 rats during the growth of the glioblastoma multiforme (strain 101/12) in the brain. The reaction of the organs of immunogenesis depended on the stage of the disease. On the 6th day after the transplantation of the tumour the increased activity of the epithelial-reticular portion of the thymus, hyperplasia of the follicles in the lymph nodes, and increased produciton of the RNA was observed. As to the tumour-bearing animals the destruction of the lymphoid elements and decreased synthesis of the RNA was noted. A giradual cell depletion of the spleen was revealed morphologically.
对92只大鼠在脑内接种多形性胶质母细胞瘤（101/12株）生长过程中，研究了淋巴网状器官（胸腺、淋巴结、脾脏）的形态学变化，并采用生化方法测定了RNA含量。免疫发生器官的反应取决于疾病阶段。肿瘤移植后第6天，观察到胸腺上皮网状部分活性增强、淋巴结滤泡增生以及RNA产生增加。至于荷瘤动物，发现淋巴样成分破坏且RNA合成减少。形态学显示脾脏细胞逐渐耗竭。
