Erokhin V N, Dronova L M, Belich E I
Biol Bull Acad Sci USSR. 1978 Sep-Oct;5(5):618-23.
The authors studied the kinetic pattern of weight change in lymph glands, spleen, thymus, and their cellular composition during the development of mouse reticulosarcomatosis and Shvets' leukosis when the transplant contained different numbers of tumor cells. They found that during the development of reticulosarcomatosis, the weight of lymph glands and their content of lymphocytes and plasmocytes undergo enormous changes; the weight of the spleen and its content of lymphocytes increase gradually while the kinetic curve of plasma cell changes presents two maxima. During the development of Shvets' leukosis, the weight of spleen and lymph glands and their lymphocyte content change enormously while the number of plasmocytes rises exponentially. In every case, the authors determined a definite dependence of the reaction of lymphoid organs on the size of the transplantate.
作者研究了小鼠网状细胞肉瘤和什韦茨白血病发展过程中，当移植瘤含有不同数量肿瘤细胞时，淋巴结、脾脏、胸腺的重量变化动力学模式及其细胞组成。他们发现，在网状细胞肉瘤发展过程中，淋巴结重量及其淋巴细胞和浆细胞含量发生巨大变化；脾脏重量及其淋巴细胞含量逐渐增加，而浆细胞变化的动力学曲线呈现两个峰值。在什韦茨白血病发展过程中，脾脏和淋巴结重量及其淋巴细胞含量变化巨大，而浆细胞数量呈指数上升。在每种情况下，作者都确定了淋巴器官反应对移植瘤大小的明确依赖性。
