Kinetics of changes in lymphoid organ weight and the cellular composition under leukosis of the latter, inoculated with different amounts of cells.

The authors studied the kinetic pattern of weight change in lymph glands, spleen, thymus, and their cellular composition during the development of mouse reticulosarcomatosis and Shvets' leukosis when the transplant contained different numbers of tumor cells. They found that during the development of reticulosarcomatosis, the weight of lymph glands and their content of lymphocytes and plasmocytes undergo enormous changes; the weight of the spleen and its content of lymphocytes increase gradually while the kinetic curve of plasma cell changes presents two maxima. During the development of Shvets' leukosis, the weight of spleen and lymph glands and their lymphocyte content change enormously while the number of plasmocytes rises exponentially. In every case, the authors determined a definite dependence of the reaction of lymphoid organs on the size of the transplantate.