Pol Stanislas, Cacoub Patrice, Pialoux Gilles, Benhamou Yves, Halfon Philippe, Rosenthal Eric, Perronne Christian
Unité d'Hépatologie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris.
Gastroenterol Clin Biol. 2007 Aug-Sep;31(8-9 Pt 3):4S7-12.
Reciprocal interactions between Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) are characterized by the absence of clear impact of HCV on HIV; by contrast, HIV markedly modified the natural history of HCV (high viral load, more severe liver disease) at least before the introduction of highly active antiretroviral therapies (HAART). HAART has completely modified the pattern of hepatic events in HIV infection and the liver disease is one of the leading causes of morbidity and mortality nowadays, reflecting several non-exclusive pathogenic processes that include drug-related hepatotoxicities, chronic hepatitis C infection, other liver diseases such as steatosis or non-alcoholic steato-hepatitis (NASH) and other liver diseases that are common in the setting of alcohol or drug abuse. The harmful impact of HIV underlines the need for improving:
人类免疫缺陷病毒（HIV）与丙型肝炎病毒（HCV）之间的相互作用表现为：HCV对HIV没有明显影响；相反，至少在高效抗逆转录病毒疗法（HAART）出现之前，HIV显著改变了HCV的自然病程（病毒载量高、肝病更严重）。HAART彻底改变了HIV感染中的肝脏病变模式，如今肝病是发病和死亡的主要原因之一，反映了几种并非相互排斥的致病过程，包括药物相关肝毒性、慢性丙型肝炎感染、其他肝脏疾病，如脂肪变性或非酒精性脂肪性肝炎（NASH），以及在酗酒或药物滥用情况下常见的其他肝脏疾病。HIV的有害影响凸显了改善以下方面的必要性：
