Piechota Mariusz, Banach Maciej, Jacoń Anna, Rysz Jacek
Department of Anaesthesiology and Intensive Care Unit, Boleslaw Szarecki University Hospital No. 5 in Łódź, Medical University in Łódź, Łódź, Poland.
Cell Mol Biol Lett. 2008;13(2):155-81. doi: 10.2478/s11658-007-0046-6. Epub 2008 Apr 10.
The natriuretic peptide family comprises atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide (DNP), and urodilatin. The activities of natriuretic peptides and endothelins are strictly associated with each other. ANP and BNP inhibit endothelin-1 (ET-1) production. ET-1 stimulates natriuretic peptide synthesis. All natriuretic peptides are synthesized from polypeptide precursors. Changes in natriuretic peptides and endothelin release were observed in many cardiovascular diseases: e.g. chronic heart failure, left ventricular dysfunction and coronary artery disease.
利钠肽家族包括心房利钠肽(ANP)、脑利钠肽(BNP)、C型利钠肽(CNP)、树眼镜蛇利钠肽(DNP)和尿钠素。利钠肽和内皮素的活性彼此密切相关。ANP和BNP抑制内皮素-1(ET-1)的产生。ET-1刺激利钠肽的合成。所有利钠肽均由多肽前体合成。在许多心血管疾病中都观察到了利钠肽和内皮素释放的变化,如慢性心力衰竭、左心室功能障碍和冠状动脉疾病。