脓毒症患者的N端脑钠肽前体水平与降钙素原及C反应蛋白水平相关。
N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients.
作者信息
Piechota Mariusz, Banach Maciej, Irzmański Robert, Misztal Małgorzata, Rysz Jacek, Barylski Marcin, Piechota-Urbańska Magdalena, Kowalski Jan, Pawlicki Lucjan
机构信息
Department of Anaesthesiology and Intensive Care Unit, Bolesław Szarecki University Hospital No. 5 in Łódź, Medical University of Łódź, Poland.
出版信息
Cell Mol Biol Lett. 2007;12(2):162-75. doi: 10.2478/s11658-006-0062-y. Epub 2006 Dec 6.
The aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80+/-84.65 pg/ml, 22.32+/-97.41 ng/ml, 128.51+/-79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor subgroup.
本研究旨在探寻脓毒症患者血浆中N末端脑钠肽前体（NT-proBNP）、降钙素原（PCT）和C反应蛋白（CRP）浓度之间的关系。这是一项在罗兹市第五医科大学附属医院开展的前瞻性研究。20例脓毒症和严重脓毒症患者纳入本研究。对N末端脑钠肽前体、降钙素原和C反应蛋白浓度以及生存率进行评估。在整个研究组（128次测量）中，NT-proBNP、降钙素原和C反应蛋白的平均浓度分别为：140.80±84.65 pg/ml、22.32±97.41 ng/ml、128.51±79.05 mg/l。NT-proBNP水平与降钙素原水平及C反应蛋白水平的相关性分别为0.3273（p<0.001）和0.4134（p<0.001）。脓毒症患者的NT-proBNP水平与PCT和CRP水平相关。在存活亚组中，NT-proBNP血浆平均浓度显著低于非存活亚组。
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