Othman Shadi F, Li Jun, Abdullah Osama, Moinnes Jessy J, Magin Richard L, Muehleman Carol
Department of Biomedical Engineering, University of Illinois, Chicago, IL, USA.
Acta Orthop. 2007 Aug;78(4):536-46. doi: 10.1080/17453670710014194.
Magnetic resonance microscopy (MRM) is an important experimental tool in the identification of early cartilage lesions.
Normal and degenerated cartilage samples were imaged at 11.74 T using a standard spin echo sequence. Quantitative MR measurements for T1, T2, and ADC were obtained and mapping for T2 and ADC was performed. The bi-exponential model for T2 relaxation was also explored. Histology was carried out for comparison with MR images.
MR images of cartilage samples displaying early stages of degeneration were positively correlated to their histological appearance in 23-microm high-resolution images and also with much shorter imaging times at 47-microm resolution. T2 maps enable delineation of the actual cartilage zones, distinguishing the superficial zone in particular. The bi-exponential model can reflect cartilage components at different stages of degeneration.
At 11.74 T, with 23-microm resolution or with 47-microm resolution and shorter imaging times, MRM provides images that allow visualization of early stages of cartilage degeneration, including superficial fibrillation. This has not been shown previously. The images also allow quantitative measurements (T1, T2, and ADC) in each cartilage region, which can be indicative of different stages of cartilage degeneration.
磁共振显微镜（MRM）是识别早期软骨损伤的重要实验工具。
使用标准自旋回波序列在11.74 T对正常和退变的软骨样本进行成像。获得T1、T2和ADC的定量磁共振测量值，并进行T2和ADC映射。还探讨了T2弛豫的双指数模型。进行组织学检查以与磁共振图像进行比较。
在23微米高分辨率图像中，显示退变早期阶段的软骨样本的磁共振图像与其组织学外观呈正相关，在47微米分辨率下成像时间也短得多。T2图能够描绘实际的软骨区域，尤其能区分表层区域。双指数模型可以反映退变不同阶段的软骨成分。
在11.74 T下，以23微米分辨率或47微米分辨率且成像时间较短时，MRM提供的图像能够显示软骨退变的早期阶段，包括表层纤维化。此前尚未有此报道。这些图像还允许在每个软骨区域进行定量测量（T1、T2和ADC），这可以指示软骨退变的不同阶段。
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