Sur Samir, Mamisch Tallal Charles, Hughes Timothy, Kim Young-Jo
Children's Hospital Boston, Department of Orthopedic Surgery, Boston, Massachusetts 02115, USA.
J Magn Reson Imaging. 2009 Oct;30(4):896-900. doi: 10.1002/jmri.21869.
To determine the feasibility of using a high resolution isotropic three-dimensional (3D) fast T1 mapping sequence for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) to assess osteoarthritis in the hip.
T1 maps of the hip were acquired using both low and high resolution techniques following the administration of 0.2 mmol/kg Gd-DTPA(2-) in 35 patients. Both T1 maps were generated from two separate spoiled GRE images. The high resolution T1 map was reconstructed in the anatomically equivalent plane as the low resolution map. T1 values from the equivalent anatomic regions containing femoral and acetabular cartilages were measured on the low and high resolution maps and compared using regression analysis.
In vivo T1 measurements showed a statistically significant correlation between the low and high resolution acquisitions at 1.5 Tesla (R(2) = 0.958, P < 0.001). These results demonstrate the feasibility of using a fast two-angle T1 mapping (F2T1) sequence with isotropic spatial resolution (0.8 x 0.8 x 0.8 mm) for quantitative assessment of biochemical status in articular cartilage of the hip.
The high resolution 3D F2T1 sequence provides accurate T1 measurements in femoral and acetabular cartilages of the hip, which enables the biochemical assessment of articular cartilage in any plane through the joint. It is a powerful tool for researchers and clinicians to acquire high resolution data in a reasonable scan time (< 30 min).
确定使用高分辨率各向同性三维（3D）快速T1映射序列进行延迟钆增强磁共振成像（dGEMRIC）以评估髋关节骨关节炎的可行性。
对35例患者静脉注射0.2 mmol/kg钆喷酸葡胺（Gd-DTPA2-）后，采用低分辨率和高分辨率技术采集髋关节的T1映射图像。两种T1映射图像均由两个单独的扰相梯度回波（GRE）图像生成。高分辨率T1映射图像在与低分辨率映射图像解剖学等效的平面上重建。在低分辨率和高分辨率映射图像上测量包含股骨和髋臼软骨的等效解剖区域的T1值，并使用回归分析进行比较。
在1.5特斯拉场强下的体内T1测量结果显示，低分辨率和高分辨率采集之间存在统计学显著相关性（R2 = 0.958，P < 0.001）。这些结果证明了使用具有各向同性空间分辨率（0.8×0.8×0.8 mm）的快速双角度T1映射（F2T1）序列对髋关节软骨生化状态进行定量评估的可行性。
高分辨率3D F2T1序列可在髋关节的股骨和髋臼软骨中提供准确的T1测量值，从而能够在通过关节的任何平面上对关节软骨进行生化评估。它是研究人员和临床医生在合理扫描时间（< 30分钟）内获取高分辨率数据的有力工具。
