Luo Man, Xie Rui-man, Quan Hong-bo, Hu Yu, Cai Ying-yun
Department of Gerontology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zhonghua Nei Ke Za Zhi. 2007 Aug;46(8):637-40.
To study the recurrence of ischemic stroke in patient with nonvalvular atrial fibrillation (NVAF) and to determine the recurrence related factors of ischemic stroke in patients with NVAF.
The clinical data of 386 NVAF patients with ischemic stroke treated in our hospital from January 1992 to February 2002 were included in this study. The basic clinical information of each patient was recorded. Analysis of recurrence and recurrence related factors of ischemic stroke in patients with NVAF was conducted.
Overall the 10-year recurrence rate of ischemic stroke in patients with NVAF was 34%. Hypertension, diabetes mellitus, transient ischemic attack (TIA), hyperlipemia and mural thrombus in left atrium were significantly correlated with the recurrence rate by univariate Cox proportional hazards regression analysis; but aspirin therapy, warfarin therapy and hypertension control were protective factors for the recurrence of ischemic stroke in patients with NVAF. Multivariate Cox proportional hazards regression analysis revealed that hypertension, TIA and mural thrombus in left atrium were independent recurrence related factors for ischemic stroke in patients with NVAF; but aspirin therapy and warfarin therapy were protective factors for the recurrence.
Hypertension, TIA and mural thrombus in left atrium were independent recurrence related factors for ischemic stroke in patient with NVAF; but aspirin therapy and warfarin therapy were protective factors for the recurrence.
研究非瓣膜性心房颤动（NVAF）患者缺血性卒中的复发情况，并确定NVAF患者缺血性卒中的复发相关因素。
纳入1992年1月至2002年2月在我院治疗的386例NVAF合并缺血性卒中患者的临床资料。记录每位患者的基本临床信息。对NVAF患者缺血性卒中的复发及复发相关因素进行分析。
总体而言，NVAF患者缺血性卒中的10年复发率为34%。单因素Cox比例风险回归分析显示，高血压、糖尿病、短暂性脑缺血发作（TIA）、高脂血症和左心房壁血栓与复发率显著相关；但阿司匹林治疗、华法林治疗和高血压控制是NVAF患者缺血性卒中复发的保护因素。多因素Cox比例风险回归分析显示，高血压、TIA和左心房壁血栓是NVAF患者缺血性卒中独立的复发相关因素；但阿司匹林治疗和华法林治疗是复发的保护因素。
高血压、TIA和左心房壁血栓是NVAF患者缺血性卒中独立的复发相关因素；但阿司匹林治疗和华法林治疗是复发的保护因素。
