辅助性T细胞17获得了核苷酸结合寡聚化结构域蛋白。

T helper 17 cells get the NOD.

作者信息

Stetson Daniel B, Medzhitov Ruslan

机构信息

Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

出版信息

Immunity. 2007 Oct;27(4):546-8. doi: 10.1016/j.immuni.2007.10.005.

DOI:10.1016/j.immuni.2007.10.005

PMID:17967409

Abstract

Interleukin-17 (IL-17)-producing helper T cells play a role in pathogen defense and autoimmunity. In this issue of Immunity, van Beelen et al. (2007) reveal a pathway that elicits potent IL-17 production from memory T cells through activation of the intracellular receptor NOD2.

摘要

产生白细胞介素-17（IL-17）的辅助性T细胞在病原体防御和自身免疫中发挥作用。在本期《免疫》杂志中，范·贝伦等人（2007年）揭示了一条通过激活细胞内受体NOD2从记忆T细胞引发高效IL-17产生的途径。