白细胞介素-12和白细胞介素-23诱导的辅助性T细胞亚群：物以类聚。
IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together.
作者信息
Bettelli Estelle, Kuchroo Vijay K
机构信息
Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
出版信息
J Exp Med. 2005 Jan 17;201(2):169-71. doi: 10.1084/jem.20042279.
Traditionally, CD4(+) T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23-driven subset of Th cells called Th(IL-17) has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whether these IL-23-induced Th(IL-17) cells are a unique subset or are related to other Th subsets is discussed.
传统上，CD4(+) T细胞已被分为两个不同的亚群，称为辅助性T细胞（Th）1和Th2。现在已经描述了一种由白细胞介素-23（IL-23）驱动的新型Th细胞亚群，称为Th(IL-17)。数据表明，IL-23在自身反应性致病性T细胞的分化中起重要作用。本文讨论了这些IL-23诱导的Th(IL-17)细胞是一个独特的亚群还是与其他Th亚群相关。
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